MyBioSource.com's MOUSE ANTI EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN is a Mouse monoclonal antibody. The MOUSE ANTI EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN Antibody was generated using Epstein-Barr Virus (EBV), Nuclear antigen, and Miscellaneous as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA.
Description
MBS214468 specifically recognises the repetitive Gly-Ala region of EBV (Epstein-Barr Virus) nuclear antigen 1 (EBNA-1), a viral protein expressed consistently by EBV- associated malignancies. Epstein-Barr Virus, also known as HHV-4 (Human herpesvirus 4), is a member of the herpesvirus family and one of the most common infectious viruses known, being responsible for a wide range of illnesses from infectious mononucleosis to nasal-pharyngeal cancer. EBNA-1 is the only viral protein expressed during group 1 latency and mediates the replication and partitioning of the episome during host cell division, binding to a replication origin (oriP) within the viral genome. The Gly-Ala repeat recognized by MBS214468, inhibits the host's CD8-restricted cytotoxic T-cell response to infected cells, by impairing antigen processing and MHC class I-restricted antigen presentation. MBS214468 is reported as being suitable for use in immunocytochemistry